Let's not beat around the bush here: The very integrity of the league is at stake here, and Goodell is watching it circle around the bowl and swirl towards the hole…not just on deflate-gate but on a host of other issues.
There's only one way to truly make a defining statement: strip the Pats of their Super Bowl title and suspend both Brady and Belichick. Given the repeat offender status, I would suspend Belichick for a year and Brady for several games. Goodell's grandstanding will amount to far less than that, obviously. And the integrity of the league will be weakened even more.
Brady, along with Manning, is the face of the league. Don't expect too much punishment.